Objective:
To determine the ability of the tablet to withstand abrasion
Introduction:
Friability is the tendency for a tablet
to chip, crumble or break following compression. This tendency is normally
confined to uncoated tablets and surfaces during handling or subsequent
storage. It can be caused by a number of factors including poor tablet design
(too sharp edges), low moisture content, insufficient binder. It is then
important that drug formulated to withstand such stress. The friability tester
has now become an accepted standard throughout the pharmaceutical industry.
Apparatus:
• Drum of tablet
abration
• Friability tester
Material:
• 10 tablets
Procedure:
1.
10 tablets are selected and weighed.
2.
All tablets are put into the drum of tablet abration
and friability tester. The rate of rotation is set to 100rpm, time is set to 10
minutes and the operation is set.
3.
At the end of operation, all the tablets are removed
and they are ensured freedom from dust or powder (brush is used). The tablets
are reweighed. The percentage loss of weight is determined.
4.
The compressed tablet should not lose more than 1% of
its weight.
Results:
Weight
of 10 tablets before testing
|
Weight
of 10 tablets after testing
|
6.57g
|
6.48g
|
6.44g
|
6.50g
|
6.51g
|
6.40g
|
6.42g
|
6.55g
|
6.60g
|
6.39g
|
6.58g
|
6.57g
|
6.50g
|
6.48g
|
6.48g
|
6.54g
|
6.53g
|
6.45g
|
6.57g
|
6.44g
|
The column for weight of 10 tablets
before and after the tablets are not directly indicated based on the column.
The weight of 10 tablets is randomly recorded in the table.
Calculations:
Mean for 10 tablets before testing
(6.57+6.44+6.51+6.42+6.60+6.58+6.50+6.48+6.53+6.57)
g / 10 = 6.52g
Mean for 10 tablets after testing
(6.48+6.50+6.40+6.55+6.39+6.57+6.48+6.54+6.45+6.44)
g / 10 = 6.48g
Percentage loss of weight = (6.52 – 6.48)
g / 6.52 g X 100%
= 0.6%
Discussion:
Tablets are constantly subjected to
mechanical shock and aberration during manufacturing, packaging and
transportation process. Such stress can lead to capping, aberration, eve
breakage of the tablets. So, in order to monitor the resistance of tablets to
such stress, tablets are routinely subjected to friability test. While the
basic design remains unchanged, considerable advances have been made in terms
of reliability and ease of usage which have now been incorporated into current
units.
Friability refers to ability of
compressed tablet to avoid fracture and breakage during transport. It is
closely related to hardness and is designed to evaluate ability of tablet to
withstand aberration in packing, handling and shipping. Friability is usually
is measured by the use of tumbler test. Friability tester has now become an
accepted standard throughout the pharmaceutical industry for determining the
resistance of uncoated tablets to the abrasion and shock experienced in
manufacturing, packing and shipping operations. Tablets need to be hard enough
such that they do not break up in the bottle but friable enough that they
disintegrate in the gastrointestinal tract. Tablet hardness has been associated
with property such as density and porosity. It is generally increase with normal
storage of tablets depend on shape, chemical properties, binding agent and
pressure applied during compression.
Conclusion:
The
tablets examined have 0.6% percentage weight of loss which does not exceed the
maximum requirement of less than 1%.
References:
References:
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